Spontaneous remission of congenital acute myeloid leukemia with t(8;16)(p11;13).

To The Editor: We report a case of congenital acute myeloid leukemia (AML) with t(8;16) that went into spontaneous remission. A full-term female presented with blueberry muffin spots at birth. A skin biopsy revealed a diffuse dermal infiltration by immature hematopoietic cells and was diagnosed as myelosarcoma (Fig. 1A and B). At Day 10, the patient’s bone marrow showed 32.8% leukemic blasts (Fig. 1C and D). A subset of the leukemic blasts was weakly positive for myeloperoxidase (MPO) and others showed weak reactivity for nonspecific esterase (NSE) (Fig. 1E and F), consistent with AML, M4 subtype by FAB criteria.